Ontology highlight
ABSTRACT:
SUBMITTER: Stamatikos A
PROVIDER: S-EPMC6383573 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Stamatikos Alexis A Dronadula Nagadhara N Ng Philip P Palmer Donna D Knight Ethan E Wacker Bradley K BK Tang Chongren C Kim Francis F Dichek David A DA
Human gene therapy 20181002 2
Atherosclerosis, a disease of blood vessels, is driven by cholesterol accumulation and inflammation. Gene therapy that removes cholesterol from blood vessels and decreases inflammation is a promising approach for prevention and treatment of atherosclerosis. In previous work, we reported that helper-dependent adenoviral (HDAd) overexpression of apolipoprotein A-I (apoAI) in endothelial cells (ECs) increases cholesterol efflux in vitro and reduces atherosclerosis in vivo. However, the effect of HD ...[more]