LATS1/2 kinases trigger self-renewal of cancer stem cells in aggressive oral cancer.
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ABSTRACT:
SUBMITTER: Nozaki M
PROVIDER: S-EPMC6383686 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Publications
LATS1/2 kinases trigger self-renewal of cancer stem cells in aggressive oral cancer.
Nozaki Masami M Yabuta Norikazu N Fukuzawa Moe M Mukai Satomi S Okamoto Ayumi A Sasakura Towa T Fukushima Kohshiro K Naito Yoko Y Longmore Gregory D GD Nojima Hiroshi H
Oncotarget 20190201 10
Cancer stem cells (CSCs), which play important roles in tumor initiation and progression, are resistant to many types of therapies. However, the regulatory mechanisms underlying CSC-specific properties, including self-renewal, are poorly understood. Here, we found that LATS1/2, the core Hippo pathway-kinases, were highly expressed in the oral squamous cell carcinoma line SAS, which exhibits high capacity of CSCs, and that depletion of these kinases prevented SAS cells from forming spheres under ...[more]
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