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A Straightforward Synthesis of Functionalized cis-Perhydroisoquinolin-1-ones.

ABSTRACT: Base-catalyzed annulation reactions of 5,6-dihydro-2(1H)-pyridones with Nazarov-type reagents are reported. The effect of the solvent polarity and the concentration of the reagents is studied. The process involves two successive Michael additions and stereoselectively provides functionalized cis-perhydroisoquinolin-1-ones.

SUBMITTER: Arioli F

PROVIDER: S-EPMC6385050 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature

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A Straightforward Synthesis of Functionalized cis-Perhydroisoquinolin-1-ones.

Arioli Federica F Pérez Maria M Are Celeste C Molins Elies E Bosch Joan J Amat Mercedes M

Molecules (Basel, Switzerland) 20190203 3

Base-catalyzed annulation reactions of 5,6-dihydro-2(1H)-pyridones with Nazarov-type reagents are reported. The effect of the solvent polarity and the concentration of the reagents is studied. The process involves two successive Michael additions and stereoselectively provides functionalized cis-perhydroisoquinolin-1-ones. ...[more]

PMID: 30717460

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