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A straightforward and convenient synthesis of functionalized allyl thiosulfonates and allyl disulfanes.

ABSTRACT: A practical, highly flexible and eco-friendly method has been developed for the synthesis of allyl thiosulfonates using Morita-Baylis-Hillman (MBH) allyl bromides and sodium arylthiosulfonates, which were readily assembled without any reagent/catalyst. Moreover, the allyl thiosulfonates were successfully transformed into a set of two synthetically viable diallyl disulfanes and unsymmetrical allyl disulfanes in the presence of Cs₂CO₃. The present protocols are operationally simple and convenient to generate a wide range of functionalized allyl thiosulfonates and allyl disulfanes in good to excellent yields.

SUBMITTER: Reddy RJ

PROVIDER: S-EPMC9091482 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

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A straightforward and convenient synthesis of functionalized allyl thiosulfonates and allyl disulfanes.

Reddy Raju Jannapu RJ Waheed Md M Kumar Jangam Jagadesh JJ

RSC advances 20181101 70

A practical, highly flexible and eco-friendly method has been developed for the synthesis of allyl thiosulfonates using Morita-Baylis-Hillman (MBH) allyl bromides and sodium arylthiosulfonates, which were readily assembled without any reagent/catalyst. Moreover, the allyl thiosulfonates were successfully transformed into a set of two synthetically viable diallyl disulfanes and unsymmetrical allyl disulfanes in the presence of Cs<sub>2</sub>CO<sub>3</sub>. The present protocols are operationally ...[more]

PMID: 35558195

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