Ontology highlight
ABSTRACT:
SUBMITTER: O'Neill BT
PROVIDER: S-EPMC6385751 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
O'Neill Brian T BT Bhardwaj Gourav G Penniman Christie M CM Krumpoch Megan T MT Suarez Beltran Pablo A PA Klaus Katherine K Poro Kennedy K Li Mengyao M Pan Hui H Dreyfuss Jonathan M JM Nair K Sreekumaran KS Kahn C Ronald CR
Diabetes 20181206 3
Insulin deficiency and uncontrolled diabetes lead to a catabolic state with decreased muscle strength, contributing to disease-related morbidity. FoxO transcription factors are suppressed by insulin and thus are key mediators of insulin action. To study their role in diabetic muscle wasting, we created mice with muscle-specific triple knockout of FoxO1/3/4 and induced diabetes in these M-FoxO-TKO mice with streptozotocin (STZ). Muscle mass and myofiber area were decreased 20-30% in STZ-Diabetes ...[more]