Ontology highlight
ABSTRACT:
SUBMITTER: Regla-Nava JA
PROVIDER: S-EPMC6386411 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Regla-Nava Jose Angel JA Viramontes Karla M KM Vozdolska Teodora T Huynh Anh-Thy AT Villani Tom T Gardner Graeme G Johnson Michael M Ferro Pamela J PJ Shresta Sujan S Kim Kenneth K
PLoS neglected tropical diseases 20190211 2
Clinical reports of Zika Virus (ZIKV) RNA detection in breast milk have been described, but evidence conflicts as to whether this RNA represents infectious virus. We infected post-parturient AG129 murine dams deficient in type I and II interferon receptors with ZIKV. ZIKV RNA was detected in pup stomach milk clots (SMC) as early as 1 day post maternal infection (dpi) and persisted as late as 7 dpi. In mammary tissues, ZIKV replication was demonstrated by immunohistochemistry in multiple cell typ ...[more]