Ontology highlight
ABSTRACT:
SUBMITTER: Rong Y
PROVIDER: S-EPMC6388693 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Rong Yaohua Y Zhao Sihai Dave SD Zhu Ji J Yuan Wei W Cheng Weihu W Li Yi Y
Statistics and its interface 20180919 4
A key step in pharmacogenomic studies is the development of accurate prediction models for drug response based on individuals' genomic information. Recent interest has centered on semiparametric models based on kernel machine regression, which can flexibly model the complex relationships between gene expression and drug response. However, performance suffers if irrelevant covariates are unknowingly included when training the model. We propose a new semiparametric regression procedure, based on a ...[more]