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Restoring Vision to the Blind with Chemical Photoswitches.


ABSTRACT: Degenerative retinal diseases such as retinitis pigmentosa (RP) and age-related macular degeneration (AMD) affect millions of people around the world and lead to irreversible vision loss if left untreated. A number of therapeutic strategies have been developed over the years to treat these diseases or restore vision to already blind patients. In this Review, we describe the development and translational application of light-sensitive chemical photoswitches to restore visual function to the blind retina and compare the translational potential of photoswitches with other vision-restoring therapies. This therapeutic strategy is enabled by an efficient fusion of chemical synthesis, chemical biology, and molecular biology and is broadly applicable to other biological systems. We hope this Review will be of interest to chemists as well as neuroscientists and clinicians.

SUBMITTER: Tochitsky I 

PROVIDER: S-EPMC6389275 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

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Restoring Vision to the Blind with Chemical Photoswitches.

Tochitsky Ivan I   Kienzler Michael A MA   Isacoff Ehud E   Kramer Richard H RH  

Chemical reviews 20180606 21


Degenerative retinal diseases such as retinitis pigmentosa (RP) and age-related macular degeneration (AMD) affect millions of people around the world and lead to irreversible vision loss if left untreated. A number of therapeutic strategies have been developed over the years to treat these diseases or restore vision to already blind patients. In this Review, we describe the development and translational application of light-sensitive chemical photoswitches to restore visual function to the blind  ...[more]

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