Bioactive Materials Facilitating Targeted Local Modulation of Inflammation.
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ABSTRACT:
SUBMITTER: Tan RP
PROVIDER: S-EPMC6390730 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Publications
Bioactive Materials Facilitating Targeted Local Modulation of Inflammation.
Tan Richard P RP Chan Alex H P AHP Wei Simon S Santos Miguel M Lee Bob S L BSL Filipe Elysse C EC Akhavan Behnam B Bilek Marcela M MM Ng Martin K C MKC Xiao Yin Y Wise Steven G SG
JACC. Basic to translational science 20190225 1
Cardiovascular disease is an inflammatory disorder that may benefit from appropriate modulation of inflammation. Systemic treatments lower cardiac events but have serious adverse effects. Localized modulation of inflammation in current standard treatments such as bypass grafting may more effectively treat CAD. The present study investigated a bioactive vascular graft coated with the macrophage polarizing cytokine interleukin-4. These grafts repolarize macrophages to anti-inflammatory phenotypes, ...[more]
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