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Longitudinal Outbreak of Multidrug-Resistant Tuberculosis in a Hospital Setting, Serbia.

ABSTRACT: A retrospective population-based molecular epidemiologic study of multidrug-resistant Mycobacterium tuberculosis complex strains in Serbia (2008-2014) revealed an outbreak of TUR genotype strains in a psychiatric hospital starting around 1990. Drug unavailability, poor infection control, and schizophrenia likely fueled acquisition of additional resistance and bacterial fitness-related mutations over 2 decades.

SUBMITTER: Arandjelovic I

PROVIDER: S-EPMC6390760 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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Longitudinal Outbreak of Multidrug-Resistant Tuberculosis in a Hospital Setting, Serbia.

Arandjelović Irena I Merker Matthias M Richter Elvira E Kohl Thomas A TA Savić Branislava B Soldatović Ivan I Wirth Thierry T Vuković Dragana D Niemann Stefan S

Emerging infectious diseases 20190301 3

A retrospective population-based molecular epidemiologic study of multidrug-resistant Mycobacterium tuberculosis complex strains in Serbia (2008-2014) revealed an outbreak of TUR genotype strains in a psychiatric hospital starting around 1990. Drug unavailability, poor infection control, and schizophrenia likely fueled acquisition of additional resistance and bacterial fitness-related mutations over 2 decades. ...[more]

PMID: 30789133

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