Ontology highlight
ABSTRACT:
SUBMITTER: Dong M
PROVIDER: S-EPMC6391147 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Dong Mengmeng M Chen Jiawen J Zhang Jiayuan J Liang Xiao X Yang Jiebing J Li Dan D Li Quanshun Q
International journal of nanomedicine 20190213
<h4>Background</h4>An amphiphilic cationic copolymer cholesterol-g-poly(amine-co-ester), namely Chol-g-PMSC-PPDL synthesized in a chemoenzymatic route has been utilized as a carrier for <i>p53</i> gene delivery to check its antitumor efficacy, using human prostate cancer cell line PC-3 (p53 null) as a model.<h4>Materials and methods</h4>The transfection efficiency was measured by quantitative PCR and Western blotting assay. The anti-proliferative effect was detected using MTT method, colony form ...[more]