A multicenter study of body mass index in cancer patients treated with anti-PD-1/PD-L1 immune checkpoint inhibitors: when overweight becomes favorable.
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ABSTRACT:
SUBMITTER: Cortellini A
PROVIDER: S-EPMC6391761 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
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A multicenter study of body mass index in cancer patients treated with anti-PD-1/PD-L1 immune checkpoint inhibitors: when overweight becomes favorable.
Cortellini Alessio A Bersanelli Melissa M Buti Sebastiano S Cannita Katia K Santini Daniele D Perrone Fabiana F Giusti Raffaele R Tiseo Marcello M Michiara Maria M Di Marino Pietro P Tinari Nicola N De Tursi Michele M Zoratto Federica F Veltri Enzo E Marconcini Riccardo R Malorgio Francesco F Russano Marco M Anesi Cecilia C Zeppola Tea T Filetti Marco M Marchetti Paolo P Botticelli Andrea A Antonini Cappellini Gian Carlo GC De Galitiis Federica F Vitale Maria Giuseppa MG Rastelli Francesca F Pergolesi Federica F Berardi Rossana R Rinaldi Silvia S Tudini Marianna M Silva Rosa Rita RR Pireddu Annagrazia A Atzori Francesco F Chiari Rita R Ricciuti Biagio B De Giglio Andrea A Iacono Daniela D Gelibter Alain A Occhipinti Mario Alberto MA Parisi Alessandro A Porzio Giampiero G Fargnoli Maria Concetta MC Ascierto Paolo Antonio PA Ficorella Corrado C Natoli Clara C
Journal for immunotherapy of cancer 20190227 1
<h4>Background</h4>Recent evidence suggested a potential correlation between overweight and the efficacy of immune checkpoint inhibitors (ICIs) in cancer patients.<h4>Patients and methods</h4>We conducted a retrospective study of advanced cancer patients consecutively treated with anti-PD-1/PD-L1 inhibitors, in order to compare clinical outcomes according to baseline BMI levels as primary analysis. Based on their BMI, patients were categorized into overweight/obese (≥ 25) and non-overweight (< 2 ...[more]
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