Ontology highlight
ABSTRACT:
SUBMITTER: Svatunek D
PROVIDER: S-EPMC6391941 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Svatunek Dennis D Houszka Nicole N Hamlin Trevor A TA Bickelhaupt F Matthias FM Mikula Hannes H
Chemistry (Weinheim an der Bergstrasse, Germany) 20181206 3
The strain-promoted alkyne-azide cycloaddition (SPAAC) is the most commonly employed bioorthogonal reaction with applications in a broad range of fields. Over the years, several different cyclooctyne derivatives have been developed and investigated in regard to their reactivity in SPAAC reactions with azides. However, only a few studies examined the influence of structurally diverse azides on reaction kinetics. Herein, we report our investigations of the reactivity of primary, secondary, and ter ...[more]