Ontology highlight
ABSTRACT:
SUBMITTER: Li X
PROVIDER: S-EPMC4128391 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Li Xiuru X Fang Tao T Boons Geert-Jan GJ
Angewandte Chemie (International ed. in English) 20140523 28
Antibody-drug conjugates hold considerable promise as anticancer agents, however, producing them remains a challenge and there is a need for mild, broadly applicable, site-specific conjugation methods that yield homogenous products. It was envisaged that enzymatic remodeling of the oligosaccharides of an antibody would enable the introduction of reactive groups that can be exploited for the site-specific attachment of cytotoxic drugs. This is based on the observation that glycosyltransferases of ...[more]