Ontology highlight
ABSTRACT:
SUBMITTER: Dean S
PROVIDER: S-EPMC6392502 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
eLife 20190227
Most motile flagella have an axoneme that contains nine outer microtubule doublets and a central pair (CP) of microtubules. The CP coordinates the flagellar beat and defects in CP projections are associated with motility defects and human disease. The CP nucleate near a 'basal plate' at the distal end of the transition zone (TZ). Here, we show that the trypanosome TZ protein 'basalin' is essential for building the basal plate, and its loss is associated with CP nucleation defects, inefficient re ...[more]