Dataset Information

Association of IL-6-174?G/C and IL10-1082?G/A polymorphisms with recurrent aphthous stomatitis risk: A meta-analysis.

ABSTRACT: BACKGROUND:Recurrent aphthous stomatitis (RAS) is a common oral disease with unknown etiology. The association between IL-6-174?G/C and IL10-1082?G/A polymorphisms and the risk of RAS remains controversial. Therefore, we conducted this meta-analysis to gain more evidence-based information. METHODS:Four online databases, PubMed, Embase, Web of Science, and Cochrane Library, were searched, and the relevant publications were collected. An odds ratio (OR) with a 95% confidence interval (CI) was applied to assess the association of the IL-6-174?G/C and IL10-1082?G/A polymorphisms with RAS susceptibility. RESULTS:Nine published case-control studies with 779 patients and 1016 controls were collected. The overall analysis proved that the IL10-1082?G/A polymorphism was significantly associated with the risk of RAS in a dominant model (GG?+?AG vs AA: OR?=?1.49, 95% CI?=?1.10-2.01, P?=?.01). A subgroup analysis based on ethnicity revealed significant associations in Asian populations in allelic, heterozygote, and dominant models (G vs A: OR?=?1.55, 95% CI?=?1.04-2.31, P?=?.03; AG vs AA: OR?=?1.76, 95% CI?=?1.16-2.67, P?=?.01; GG?+?AG vs AA: OR?=?2.04, 95% CI?=?1.37-3.03, P?=?.00). The association in Caucasians and people of mixed ethnicity requires further study. No significant association was detected between the IL-6-174?G/C polymorphism and RAS in any of the genetic models. However, subgroup analysis by ethnicity revealed that the Caucasians were more likely to develop RAS in 4 genetic models (G vs C: OR?=?2.36, 95% CI?=?1.26-4.41, P?=?.01; GG vs CC: OR?=?7.05, 95% CI?=?3.50-14.18, P?=?.00; GG?+?CG vs CC: OR?=?4.28, 95% CI?=?2.17-8.45, P?=?.00; GG vs CG?+?CC: OR?=?2.59, 95% CI?=?1.05-6.41, P?=?.04). In addition, a significantly decreased risk of RAS susceptibility was found in Asians (CG vs CC: OR?=?0.27, 95% CI?=?0.07-0.99, P?=?.049; GG?+?CG vs CC: OR?=?0.27, 95% CI?=?0.07-0.98, P?=?.047). CONCLUSION:Our meta-analysis indicated that the IL10-1082?G/A polymorphism is associated with RAS susceptibility, especially in Asians. In contrast, the IL-6-174?G/C polymorphism does not have a statistically significant association with RAS susceptibility. However, it may play a different role during the development of RAS in different ethnicities.

SUBMITTER: Yang S

PROVIDER: S-EPMC6392591 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature

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Association of IL-6-174 G/C and IL10-1082 G/A polymorphisms with recurrent aphthous stomatitis risk: A meta-analysis.

Yang Shuo S Zhang Bin B Shi Quan Q Liu Jinglong J Xu Juan J Huo Na N

Medicine 20171201 52

<h4>Background</h4>Recurrent aphthous stomatitis (RAS) is a common oral disease with unknown etiology. The association between IL-6-174 G/C and IL10-1082 G/A polymorphisms and the risk of RAS remains controversial. Therefore, we conducted this meta-analysis to gain more evidence-based information.<h4>Methods</h4>Four online databases, PubMed, Embase, Web of Science, and Cochrane Library, were searched, and the relevant publications were collected. An odds ratio (OR) with a 95% confidence interva ...[more]

PMID: 29384969

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Project description:Recurrent aphthous stomatitis (RAS) is the most common disease affecting oral mucosae. Etiology is unknown, but several factors have been implicated, all of which influence the composition of microbiota residing on oral mucosae, which in turn modulates immunity and thereby affects disease progression. Although no individual pathogens have been conclusively shown to be causative agents of RAS, imbalanced composition of the oral microbiota may play a key role. In this study, we sought to determine composition profiles of bacterial microbiota in the oral mucosa associated with RAS. Using high-throughput 16S rRNA gene sequencing, we characterized the most abundant bacterial populations residing on healthy and ulcerated mucosae in patients with RAS (recruited using highly stringent criteria) and no associated medical conditions; we also compared these to the bacterial microbiota of healthy controls (HCs). Phylum-level diversity comparisons revealed decreased Firmicutes and increased Proteobacteria in ulcerated sites, as compared with healthy sites in RAS patients, and no differences between RAS patients with healthy sites and HCs. Genus-level analysis demonstrated higher abundance of total Bacteroidales in RAS patients with healthy sites over HCs. Porphyromonadaceae comprising species associated with periodontal disease and Veillonellaceae predominated in ulcerated sites over HCs, while no quantitative differences of these families were observed between healthy sites in RAS patients and HCs. Streptococcaceae comprising species associated with oral health predominated in HCs over ulcerated sites but not in HCs over healthy sites in RAS patients. This study demonstrates that mucosal microbiome changes in patients with idiopathic RAS--namely, increased Bacteroidales species in mucosae of RAS patients not affected by active ulceration. While these changes suggest a microbial role in initiation of RAS, this study does not provide data on causality. Within this limitation, the study contributes to the understanding of the potential role of mucosal microbiome changes in oral mucosal disease.

Project description:BackgroundInterleukin (IL)-6 and IL-10 are the most important cytokine with pro and anti-inflammatory activities, respectively. Dysregulation of IL-6 and IL-10 are associated with increased risk of developing Type 2 Diabetes Mellitus (T2DM). Despite this, a fundamental understanding of both cytokine gene polymorphisms with its expression is critical in understanding of cellular mechanism of insulin resistance as well as T2DM intervention. Therefore, this study aimed to assess IL-6 (- 174 G/C) and IL-10 (- 1082 A/G) gene polymorphism, and its association with T2DM, North West Ethiopia.MethodsA comparative cross-sectional study from January to May 2018 was conducted on study participants with T2DM and apparently healthy controls. Deoxyribonucleic acid (DNA) extraction and genotyping was carried out by using amplification refractory mutation system polymerase chain reaction to detect polymorphism of IL-6 and IL-10 gene at the position - 174 and - 1082, respectively. The logistic regression model was fitted to assess the association of between cytokine gene polymorphisms and T2DM. Odds ratio with 95% CI was determined to assess the presence and strength of association between the explanatory variables and outcome variable. A P-value < 0.05 was considered as statistically significant.ResultParticipants carrying the GG genotype of IL-6 (- 174) (OR (95% CI) = 4.61 (2.07-10.54) was a high likelihood of having T2DM compared to those carrying the CC and AA genotypes. AA and AG genotypes of IL-10 (- 1082) were at lower odd of developing T2DM compared to those carrying the GG genotype. In addition, individuals carrying the G allele of IL-6 (- 174) have 2.82-fold odds of developing T2DM compared to individuals carrying the C allele (OR (95% CI) =2.81 (1.78-4.50)).ConclusionOur study revealed that genetic polymorphisms of IL-6 (- 174) GG genotype is the potential host genetic risk factors to T2DM. While, IL-10 (- 1082) AA genotype is negatively associated with T2DM. Therefore, IL-6 (- 174) and IL-10 (- 1082) genetic variation may be considered as a biomarker for early screening and diagnosis of T2DM.

Dataset Information

Association of IL-6-174?G/C and IL10-1082?G/A polymorphisms with recurrent aphthous stomatitis risk: A meta-analysis.

Publications

Association of IL-6-174 G/C and IL10-1082 G/A polymorphisms with recurrent aphthous stomatitis risk: A meta-analysis.

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