Dataset Information

Association between IL-6 -174 G/C, IL-6 -634 G/C, and IFN-? +874 A/T polymorphisms and susceptibility to recurrent pregnancy loss: a meta-analysis.

ABSTRACT: The aim of this study was to determine whether interleukin-6 (IL-6) -174 G/C, IL-6 -634 G/C, and interferon-? (IFN-?) +874 A/T polymorphisms are associated with susceptibility to recurrent pregnancy loss (RPL).We conducted a literature search using PubMed and EMBASE databases and performed a meta-analysis using fixed- or random-effects models.A total of 15 articles met the study inclusion criteria. When all study subjects were considered together, meta-analysis showed no association between RPL and the IL-6 -174 GG?+?GC genotype (odds ratio [OR]?=?0.794, 95 % confidence interval [CI]?=?0.542-1.163, p?=?0.236). However, stratification of the data by ethnicity indicated an association between this genotype and RPL in non-Caucasians (OR?=?0.528, 95 % CI?=?0.302-0.925, p?=?0.028), but not in Caucasian populations. Moreover, meta-analysis revealed an association between RPL and the IL-6 -634 GG?+?GC genotype in all study subjects (OR?=?0.556, 95 % CI?=?0.383-0.806, p?=?0.002), while stratification by ethnicity revealed a negative association between this genotype and RPL in Asian (OR?=?0.545, 95 % CI?=?0.371-0.800, p?=?0.002) but not Middle Eastern populations. Furthermore, a relationship between the IFN-? +874 A allele and RPL was identified in non-Caucasians (OR?=?1.403, 95 % CI?=?1.133-1.734, p?=?0.002), but not in Caucasians.This meta-analysis demonstrates that IL-6 -174 G/C, IL-6 -634 G/C, and IFN-? +874 A/T polymorphisms are associated with susceptibility to RPL, particularly in non-Caucasians.

SUBMITTER: Lee YH

PROVIDER: S-EPMC4595406 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature

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Publications

Association between IL-6 -174 G/C, IL-6 -634 G/C, and IFN-γ +874 A/T polymorphisms and susceptibility to recurrent pregnancy loss: a meta-analysis.

Lee Young Ho YH Choi Sung Jae SJ Ji Jong Dae JD

Journal of assisted reproduction and genetics 20150904 9

<h4>Objective</h4>The aim of this study was to determine whether interleukin-6 (IL-6) -174 G/C, IL-6 -634 G/C, and interferon-γ (IFN-γ) +874 A/T polymorphisms are associated with susceptibility to recurrent pregnancy loss (RPL).<h4>Methods</h4>We conducted a literature search using PubMed and EMBASE databases and performed a meta-analysis using fixed- or random-effects models.<h4>Results</h4>A total of 15 articles met the study inclusion criteria. When all study subjects were considered together ...[more]

PMID: 26341097

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Project description:BACKGROUND:Recurrent aphthous stomatitis (RAS) is a common oral disease with unknown etiology. The association between IL-6-174?G/C and IL10-1082?G/A polymorphisms and the risk of RAS remains controversial. Therefore, we conducted this meta-analysis to gain more evidence-based information. METHODS:Four online databases, PubMed, Embase, Web of Science, and Cochrane Library, were searched, and the relevant publications were collected. An odds ratio (OR) with a 95% confidence interval (CI) was applied to assess the association of the IL-6-174?G/C and IL10-1082?G/A polymorphisms with RAS susceptibility. RESULTS:Nine published case-control studies with 779 patients and 1016 controls were collected. The overall analysis proved that the IL10-1082?G/A polymorphism was significantly associated with the risk of RAS in a dominant model (GG?+?AG vs AA: OR?=?1.49, 95% CI?=?1.10-2.01, P?=?.01). A subgroup analysis based on ethnicity revealed significant associations in Asian populations in allelic, heterozygote, and dominant models (G vs A: OR?=?1.55, 95% CI?=?1.04-2.31, P?=?.03; AG vs AA: OR?=?1.76, 95% CI?=?1.16-2.67, P?=?.01; GG?+?AG vs AA: OR?=?2.04, 95% CI?=?1.37-3.03, P?=?.00). The association in Caucasians and people of mixed ethnicity requires further study. No significant association was detected between the IL-6-174?G/C polymorphism and RAS in any of the genetic models. However, subgroup analysis by ethnicity revealed that the Caucasians were more likely to develop RAS in 4 genetic models (G vs C: OR?=?2.36, 95% CI?=?1.26-4.41, P?=?.01; GG vs CC: OR?=?7.05, 95% CI?=?3.50-14.18, P?=?.00; GG?+?CG vs CC: OR?=?4.28, 95% CI?=?2.17-8.45, P?=?.00; GG vs CG?+?CC: OR?=?2.59, 95% CI?=?1.05-6.41, P?=?.04). In addition, a significantly decreased risk of RAS susceptibility was found in Asians (CG vs CC: OR?=?0.27, 95% CI?=?0.07-0.99, P?=?.049; GG?+?CG vs CC: OR?=?0.27, 95% CI?=?0.07-0.98, P?=?.047). CONCLUSION:Our meta-analysis indicated that the IL10-1082?G/A polymorphism is associated with RAS susceptibility, especially in Asians. In contrast, the IL-6-174?G/C polymorphism does not have a statistically significant association with RAS susceptibility. However, it may play a different role during the development of RAS in different ethnicities.

Project description:Study questionWhat is the recommended management of women with recurrent pregnancy loss (RPL) based on the best available evidence in the literature?Summary answerThe guideline development group formulated 77 recommendations answering 18 key questions on investigations and treatments for RPL, and on how care should be organized.What is known alreadyA previous guideline for the investigation and medical treatment of recurrent miscarriage was published in 2006 and is in need of an update.Study design size durationThe guideline was developed according to the structured methodology for development of ESHRE guidelines. After formulation of key questions by a group of experts, literature searches and assessments were performed. Papers published up to 31 March 2017 and written in English were included. Cumulative live birth rate, live birth rate and pregnancy loss rate (or miscarriage rate) were considered the critical outcomes.Participants/materials setting methodsBased on the collected evidence, recommendations were formulated and discussed until consensus was reached within the guideline group. A stakeholder review was organized after finalization of the draft. The final version was approved by the guideline group and the ESHRE Executive Committee.Main results and the role of chanceThe guideline provides 38 recommendations on risk factors, prevention and investigations in couples with RPL, and 39 recommendations on treatments. These include 60 evidence-based recommendations - of which 31 were formulated as strong recommendations and 29 as conditional - and 17 good practice points. The evidence supporting investigations and treatment of couples with RPL is limited and of moderate quality. Of the evidence-based recommendations, only 10 (16.3%) were supported by moderate quality evidence. The remaining recommendations were supported by low (35 recommendations: 57.4%), or very low quality evidence (16 recommendations: 26.2%). There were no recommendations based on high quality evidence. Owing to the lack of evidence-based investigations and treatments in RPL care, the guideline also clearly mentions investigations and treatments that should not be used for couples with RPL.Limitations reasons for cautionSeveral investigations and treatments are offered to couples with RPL, but most of them are not well studied. For most of these investigations and treatments, a recommendation against the intervention or treatment was formulated based on insufficient evidence. Future studies may require these recommendations to be revised.Wider implications of the findingsThe guideline provides clinicians with clear advice on best practice in RPL, based on the best evidence available. In addition, a list of research recommendations is provided to stimulate further studies in RPL. One of the most important consequences of the limited evidence is the absence of evidence for a definition of RPL.Study funding/competing interestsThe guideline was developed and funded by ESHRE, covering expenses associated with the guideline meetings, with the literature searches and with the dissemination of the guideline. The guideline group members did not receive payment. J.E. reports position funding from CARE Fertility. S.L. reports position funding from SpermComet Ltd. S.M. reports research grants, consulting and speaker's fees from GSK, BMS/Pfizer, Sanquin, Aspen, Bayer and Daiichi Sankyo. S.Q. reports speaker's fees from Ferring. The other authors report no conflicts of interest.ESHRE Pages are not externally peer reviewed. This article has been approved by the Executive Committee of ESHRE.

Dataset Information

Association between IL-6 -174 G/C, IL-6 -634 G/C, and IFN-? +874 A/T polymorphisms and susceptibility to recurrent pregnancy loss: a meta-analysis.

Publications

Association between IL-6 -174 G/C, IL-6 -634 G/C, and IFN-γ +874 A/T polymorphisms and susceptibility to recurrent pregnancy loss: a meta-analysis.

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