The association between PIN1 genetic polymorphisms and the risk of chronic hepatitis B and hepatitis B virus-related liver cirrhosis: A case-control study.

ABSTRACT: Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 (PIN1) reportedly plays a crucial role in tissue inflammation and tumourigenesis. Our previous studies have demonstrated that PIN1 gene polymorphisms are significantly related to the pathogenesis of hepatitis B virus (HBV)-related liver cancer in a Guangxi population. As chronic hepatitis B (CHB), liver cirrhosis (LC), and liver cancer are development processes, we further investigated whether any relationship exists between PIN1 gene polymorphisms and the risk of CHB and HBV-related LC. We used the polymerase chain reaction restriction fragment length polymorphism and the deoxyribonucleic acid sequencing method to analyze 3 common single-nucleotide polymorphisms (SNPs) (rs2233678, rs2233679, and rs2233682) of the PIN1 gene in 192 CHB patients, 171 HBV-related LC patients, and 201 healthy controls in this research. The results revealed that carriers of the rs2233682 A allele had a significantly decreased risk of HBV-related LC (LC vs. controls: odds ratio [OR]?=?0.262, 95% confidence interval [CI]?=?0.071-0.959, P?=?.043; LC vs. CHB: OR?=?0.198, 95% CI?=?0.049-0.803, P?=?.023). Similar relationships were observed for the PIN1 rs2233682 GA genotype among the groups (LC vs. controls: OR?=?0.248, 95% CI?=?0.067-0.919, P?=?.037; LC vs. CHB: OR?=?0.184, 95% CI?=?0.044-0.773, P?=?.021). This reduced risk was more obvious in older CHB patients (age ?50 years). No such correlations were found for PIN1 rs2233678 and rs2233679. However, the haplotypes constructed from these SNP (GCA for controls and CCG for CHB) were associated with a significantly decreased risk of HBV-related LC. In summary, the findings of this study suggest that the PIN1 rs2233682 A allele might be related with a decreased risk of HBV-related LC in a Guangxi population.

SUBMITTER: Huang L 

PROVIDER: S-EPMC6392626 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature