Ontology highlight
ABSTRACT:
SUBMITTER: Tong Y
PROVIDER: S-EPMC6392673 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Tong Yu Y Wang Huiqing H Li Shiping S Zhao Fengyan F Ying Junjie J Qu Yi Y Mu Dezhi D
Medicine 20180801 35
Genome-wide association studies (GWAS) have identified multiple independent cancer susceptibility loci at chromosome 8q24.We conducted a comprehensive research synopsis and meta-analysis to evaluate associations between 6 variants in 8q24 and risk of colorectal cancer using data from 31 eligible articles totaling 41,942 cases and 49,968 controls.Of the 6 variants located in 8q24, 3 were significantly associated with risk of colorectal cancer. In particular, both homozygous TT and heterozygous CT ...[more]