Rationally designed carbohydrate-occluded epitopes elicit HIV-1 Env-specific antibodies.
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ABSTRACT:
SUBMITTER: Zhu C
PROVIDER: S-EPMC6393580 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Publications
Rationally designed carbohydrate-occluded epitopes elicit HIV-1 Env-specific antibodies.
Zhu Cheng C Dukhovlinova Elena E Council Olivia O Ping Lihua L Faison Edgar M EM Prabhu Shamit S SS Potter E Lake EL Upton Stephen L SL Yin Guowei G Fay James M JM Kincer Laura P LP Spielvogel Ean E Campbell Sharon L SL Benhabbour S Rahima SR Ke Hengming H Swanstrom Ronald R Dokholyan Nikolay V NV
Nature communications 20190227 1
An array of carbohydrates masks the HIV-1 surface protein Env, contributing to the evasion of humoral immunity. In most HIV-1 isolates 'glycan holes' occur due to natural sequence variation, potentially revealing the underlying protein surface to the immune system. Here we computationally design epitopes that mimic such surface features (carbohydrate-occluded neutralization epitopes or CONE) of Env through 'epitope transplantation', in which the target region is presented on a carrier protein sc ...[more]
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