Ontology highlight
ABSTRACT:
SUBMITTER: Dosenovic P
PROVIDER: S-EPMC6780999 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Dosenovic Pia P Pettersson Anna-Klara AK Wall Abigail A Thientosapol Eddy S ES Feng Junli J Weidle Connor C Bhullar Komal K Kara Ervin E EE Hartweger Harald H Pai Joy A JA Gray Matthew D MD Parks K Rachael KR Taylor Justin J JJ Pancera Marie M Stamatatos Leonidas L Nussenzweig Michel C MC McGuire Andrew T AT
The Journal of experimental medicine 20190725 10
Human anti-HIV-1 broadly neutralizing antibodies (bNAbs) protect against infection in animal models. However, bNAbs have not been elicited by vaccination in diverse wild-type animals or humans, in part because B cells expressing the precursors of these antibodies do not recognize most HIV-1 envelopes (Envs). Immunogens have been designed that activate these B cell precursors in vivo, but they also activate competing off-target responses. Here we report on a complementary approach to expand speci ...[more]