Accuracy of the new rapid test for monitoring adalimumab levels.

ABSTRACT:

Background

The loss of response to adalimumab (ADL) has been related to low serum concentrations at trough. Currently, most methods commercially available for the quantification of ADL are enzyme-linked immunosorbent assay (ELISA) based, with a turnaround time of approximately 8 h, delaying the target dosage adjustment to the subsequent infusion. In this study, we aimed to evaluate the performance of the newly available rapid-test ADL quantification assay by comparing it with three established ELISA methods, using spiked samples and a set of clinical samples.

Methods

Spiked samples from control donors and 120 serum samples from inflammatory bowel disease (IBD) patients undergoing ADL therapy were quantified using lateral flow Quantum Blue^® Adalimumab and, the ELIS

SUBMITTER: Rocha C 

PROVIDER: S-EPMC6393825 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature