Ontology highlight
ABSTRACT:
SUBMITTER: Verger A
PROVIDER: S-EPMC6393861 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Verger Alexis A Monté Didier D Villeret Vincent V
Biochemical Society transactions 20190207 1
Mediator is a large multiprotein complex conserved in all eukaryotes that plays an essential role in transcriptional regulation. Mediator comprises 25 subunits in yeast and 30 subunits in humans that form three main modules and a separable four-subunit kinase module. For nearly 20 years, because of its size and complexity, Mediator has posed a formidable challenge to structural biologists. The first two-dimensional electron microscopy (EM) projection map of Mediator leading to the canonical view ...[more]