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Reactivation of hepatitis B virus infection in patients with hematologic disorders.


ABSTRACT: Hepatitis B reactivation is the reappearance or rise of hepatitis B virus (HBV) DNA in patients with past or chronic HBV infection, usually occurring in the context of immunosuppression. HBV reactivation has been most commonly reported in patients with hematologic disorders, with potentially serious and life-threatening consequences. In this review, we discuss the basis and presentation of HBV reactivation, and risk factors in terms of the host, the virus and the immunosuppression regimen, including newer agents used to manage hematologic malignancies. We overview the management of HBV reactivation, highlighting an up-dated recommendation on the use of newer nucleoside and nucleotide analogs, such as tenofovir and entecavir, for antiviral prophylaxis.

SUBMITTER: Wang B 

PROVIDER: S-EPMC6395346 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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Reactivation of hepatitis B virus infection in patients with hematologic disorders.

Wang Bo B   Mufti Ghulam G   Agarwal Kosh K  

Haematologica 20190207 3


Hepatitis B reactivation is the reappearance or rise of hepatitis B virus (HBV) DNA in patients with past or chronic HBV infection, usually occurring in the context of immunosuppression. HBV reactivation has been most commonly reported in patients with hematologic disorders, with potentially serious and life-threatening consequences. In this review, we discuss the basis and presentation of HBV reactivation, and risk factors in terms of the host, the virus and the immunosuppression regimen, inclu  ...[more]

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