Ontology highlight
ABSTRACT:
SUBMITTER: Kim WY
PROVIDER: S-EPMC6395725 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Kim Wan-Young WY Nam Sun Ah SA Choi Arum A Kim Yu-Mi YM Park Sang Hee SH Kim Hong Lim HL Kim Hyang H Han Ki-Hwan KH Yang Chul Woo CW Lee Myung-Shik MS Kim Yong Kyun YK Kim Jin J
Scientific reports 20190228 1
Prolonged hypokalemia induces a decrease of urinary concentrating ability via down-regulation of aquaporin 2 (AQP2); however, the precise mechanisms remain unknown. To investigate the role of autophagy in the degradation of AQP2, we generated the principal cell-specific Atg7 deletion (Atg7<sup>Δpc</sup>) mice. In hypokalemic Atg7-floxed (Atg7<sup>f/f</sup>) mice, huge irregular shaped LC3-positive autophagic vacuoles accumulated mainly in inner medullary collecting duct (IMCD) cells. Total- and ...[more]