Ontology highlight
ABSTRACT:
SUBMITTER: de Vries PS
PROVIDER: S-EPMC6396174 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
de Vries Paul S PS Sabater-Lleal Maria M Huffman Jennifer E JE Marten Jonathan J Song Ci C Pankratz Nathan N Bartz Traci M TM de Haan Hugoline G HG Delgado Graciela E GE Eicher John D JD Martinez-Perez Angel A Ward-Caviness Cavin K CK Brody Jennifer A JA Chen Ming-Huei MH de Maat Moniek P M MPM Frånberg Mattias M Gill Dipender D Kleber Marcus E ME Rivadeneira Fernando F Soria José Manuel JM Tang Weihong W Tofler Geoffrey H GH Uitterlinden André G AG van Hylckama Vlieg Astrid A Seshadri Sudha S Boerwinkle Eric E Davies Neil M NM Giese Anne-Katrin AK Ikram M Kamran MK Kittner Steven J SJ McKnight Barbara B Psaty Bruce M BM Reiner Alex P AP Sargurupremraj Muralidharan M Taylor Kent D KD Fornage Myriam M Hamsten Anders A März Winfried W Rosendaal Frits R FR Souto Juan Carlos JC Dehghan Abbas A Johnson Andrew D AD Morrison Alanna C AC O'Donnell Christopher J CJ Smith Nicholas L NL
Blood 20190114 9
Factor VII (FVII) is an important component of the coagulation cascade. Few genetic loci regulating FVII activity and/or levels have been discovered to date. We conducted a meta-analysis of 9 genome-wide association studies of plasma FVII levels (7 FVII activity and 2 FVII antigen) among 27 495 participants of European and African ancestry. Each study performed ancestry-specific association analyses. Inverse variance weighted meta-analysis was performed within each ancestry group and then combin ...[more]