Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa.
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ABSTRACT:
SUBMITTER: Watson HJ
PROVIDER: S-EPMC6779477 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
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Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa.
Watson Hunna J HJ Yilmaz Zeynep Z Thornton Laura M LM Hübel Christopher C Coleman Jonathan R I JRI Gaspar Héléna A HA Bryois Julien J Hinney Anke A Leppä Virpi M VM Mattheisen Manuel M Medland Sarah E SE Ripke Stephan S Yao Shuyang S Giusti-Rodríguez Paola P Hanscombe Ken B KB Purves Kirstin L KL Adan Roger A H RAH Alfredsson Lars L Ando Tetsuya T Andreassen Ole A OA Baker Jessica H JH Berrettini Wade H WH Boehm Ilka I Boni Claudette C Perica Vesna Boraska VB Buehren Katharina K Burghardt Roland R Cassina Matteo M Cichon Sven S Clementi Maurizio M Cone Roger D RD Courtet Philippe P Crow Scott S Crowley James J JJ Danner Unna N UN Davis Oliver S P OSP de Zwaan Martina M Dedoussis George G Degortes Daniela D DeSocio Janiece E JE Dick Danielle M DM Dikeos Dimitris D Dina Christian C Dmitrzak-Weglarz Monika M Docampo Elisa E Duncan Laramie E LE Egberts Karin K Ehrlich Stefan S Escaramís Geòrgia G Esko Tõnu T Estivill Xavier X Farmer Anne A Favaro Angela A Fernández-Aranda Fernando F Fichter Manfred M MM Fischer Krista K Föcker Manuel M Foretova Lenka L Forstner Andreas J AJ Forzan Monica M Franklin Christopher S CS Gallinger Steven S Giegling Ina I Giuranna Johanna J Gonidakis Fragiskos F Gorwood Philip P Mayora Monica Gratacos MG Guillaume Sébastien S Guo Yiran Y Hakonarson Hakon H Hatzikotoulas Konstantinos K Hauser Joanna J Hebebrand Johannes J Helder Sietske G SG Herms Stefan S Herpertz-Dahlmann Beate B Herzog Wolfgang W Huckins Laura M LM Hudson James I JI Imgart Hartmut H Inoko Hidetoshi H Janout Vladimir V Jiménez-Murcia Susana S Julià Antonio A Kalsi Gursharan G Kaminská Deborah D Kaprio Jaakko J Karhunen Leila L Karwautz Andreas A Kas Martien J H MJH Kennedy James L JL Keski-Rahkonen Anna A Kiezebrink Kirsty K Kim Youl-Ri YR Klareskog Lars L Klump Kelly L KL Knudsen Gun Peggy S GPS La Via Maria C MC Le Hellard Stephanie S Levitan Robert D RD Li Dong D Lilenfeld Lisa L Lin Bochao Danae BD Lissowska Jolanta J Luykx Jurjen J Magistretti Pierre J PJ Maj Mario M Mannik Katrin K Marsal Sara S Marshall Christian R CR Mattingsdal Morten M McDevitt Sara S McGuffin Peter P Metspalu Andres A Meulenbelt Ingrid I Micali Nadia N Mitchell Karen K Monteleone Alessio Maria AM Monteleone Palmiero P Munn-Chernoff Melissa A MA Nacmias Benedetta B Navratilova Marie M Ntalla Ioanna I O'Toole Julie K JK Ophoff Roel A RA Padyukov Leonid L Palotie Aarno A Pantel Jacques J Papezova Hana H Pinto Dalila D Rabionet Raquel R Raevuori Anu A Ramoz Nicolas N Reichborn-Kjennerud Ted T Ricca Valdo V Ripatti Samuli S Ritschel Franziska F Roberts Marion M Rotondo Alessandro A Rujescu Dan D Rybakowski Filip F Santonastaso Paolo P Scherag André A Scherer Stephen W SW Schmidt Ulrike U Schork Nicholas J NJ Schosser Alexandra A Seitz Jochen J Slachtova Lenka L Slagboom P Eline PE Slof-Op 't Landt Margarita C T MCT Slopien Agnieszka A Sorbi Sandro S Świątkowska Beata B Szatkiewicz Jin P JP Tachmazidou Ioanna I Tenconi Elena E Tortorella Alfonso A Tozzi Federica F Treasure Janet J Tsitsika Artemis A Tyszkiewicz-Nwafor Marta M Tziouvas Konstantinos K van Elburg Annemarie A AA van Furth Eric F EF Wagner Gudrun G Walton Esther E Widen Elisabeth E Zeggini Eleftheria E Zerwas Stephanie S Zipfel Stephan S Bergen Andrew W AW Boden Joseph M JM Brandt Harry H Crawford Steven S Halmi Katherine A KA Horwood L John LJ Johnson Craig C Kaplan Allan S AS Kaye Walter H WH Mitchell James E JE Olsen Catherine M CM Pearson John F JF Pedersen Nancy L NL Strober Michael M Werge Thomas T Whiteman David C DC Woodside D Blake DB Stuber Garret D GD Gordon Scott S Grove Jakob J Henders Anjali K AK Juréus Anders A Kirk Katherine M KM Larsen Janne T JT Parker Richard R Petersen Liselotte L Jordan Jennifer J Kennedy Martin M Montgomery Grant W GW Wade Tracey D TD Birgegård Andreas A Lichtenstein Paul P Norring Claes C Landén Mikael M Martin Nicholas G NG Mortensen Preben Bo PB Sullivan Patrick F PF Breen Gerome G Bulik Cynthia M CM
Nature genetics 20190715 8
Characterized primarily by a low body-mass index, anorexia nervosa is a complex and serious illness<sup>1</sup>, affecting 0.9-4% of women and 0.3% of men<sup>2-4</sup>, with twin-based heritability estimates of 50-60%<sup>5</sup>. Mortality rates are higher than those in other psychiatric disorders<sup>6</sup>, and outcomes are unacceptably poor<sup>7</sup>. Here we combine data from the Anorexia Nervosa Genetics Initiative (ANGI)<sup>8,9</sup> and the Eating Disorders Working Group of the Psyc ...[more]
