Adiponectin regulates bone mass in AIS osteopenia via RANKL/OPG and IL6 pathway.

ABSTRACT:

Background

Osteopenia have been well documented in adolescent idiopathic scoliosis (AIS). Adiponectin has been shown to be inversely proportional to body mass index and to affect bone metabolism. However, the circulating levels of adiponectin and the relationship between adiponectin and low bone mass in AIS remain unclear.

Methods

A total of 563 AIS and 281 age-matched controls were recruited for this study. Anthropometry and bone mass were measured in all participants. Plasma adiponectin levels were determined by enzyme-linked immunosorbent assay (ELISA) in the AIS and control groups. An improved multiplex ligation detection reaction was performed to study on single nucleotide polymorphism. Facet joints were collected and used to measure the microstructure, the expression o

SUBMITTER: Zhang HQ 

PROVIDER: S-EPMC6396498 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature