Ontology highlight
ABSTRACT:
SUBMITTER: Sarogni P
PROVIDER: S-EPMC6397456 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Sarogni Patrizia P Palumbo Orazio O Servadio Adele A Astigiano Simonetta S D'Alessio Barbara B Gatti Veronica V Cukrov Dubravka D Baldari Silvia S Pallotta Maria Michela MM Aretini Paolo P Dell'Orletta Felice F Soddu Silvia S Carella Massimo M Toietta Gabriele G Barbieri Ottavia O Fontanini Gabriella G Musio Antonio A
Journal of experimental & clinical cancer research : CR 20190301 1
<h4>Background</h4>Cancer cells are characterized by chromosomal instability (CIN) and it is thought that errors in pathways involved in faithful chromosome segregation play a pivotal role in the genesis of CIN. Cohesin forms a large protein ring that binds DNA strands by encircling them. In addition to this central role in chromosome segregation, cohesin is also needed for DNA repair, gene transcription regulation and chromatin architecture. Though mutations in both cohesin and cohesin-regulato ...[more]