Ontology highlight
ABSTRACT:
SUBMITTER: Tang M
PROVIDER: S-EPMC6398038 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Tang Min M Chen Rui R Wang Hao H Sun Guowei G Yin Fan F Liang Beibei B Yang Yang Y Sharen Gaowa G Wei Huafeng H Zhou Xuyu X Huang Gang G Zhao Jian J
Stem cells international 20190217
Obesity is a major risk factor for many chronic diseases, including diabetes, fatty livers, and cancer. Expansion of the adipose mass has been shown to be related to adipogenic differentiation of adipose-derived mesenchymal stem cells (ASCs). However, the underlying mechanism of this effect has yet to be elucidated. We found that osteopontin (OPN) is downregulated in ASCs and adipose tissues of obese mice and overweight human beings because of methylation on its promoter, indicating that OPN may ...[more]