Structural insight into Wnt signaling inhibition by Clostridium difficile toxin B.
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ABSTRACT:
SUBMITTER: Chen P
PROVIDER: S-EPMC6399045 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Publications
Structural insight into Wnt signaling inhibition by Clostridium difficile toxin B.
Chen Peng P Tao Liang L Liu Zheng Z Dong Min M Jin Rongsheng R
The FEBS journal 20181101 5
The incidence of Clostridium difficile infection (CDI) has increased significantly worldwide, causing substantial morbidity and mortality. One of the major virulence factor, TcdB, manages to enter the colonic epithelia via the human frizzled proteins (FZDs), which are physiological receptors for Wnt morphogens. Binding of TcdB to FZDs inhibits Wnt signaling, which may contribute to pathogenesis of CDI. Here, we review the structural mechanism by which TcdB exploits to recognize FZDs for cell ent ...[more]
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