Ontology highlight
ABSTRACT:
SUBMITTER: Ahmed AR
PROVIDER: S-EPMC6399282 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Ahmed Abdullah R AR Owens Raymond J RJ Stubbs Christopher D CD Parker Anthony W AW Hitchman Richard R Yadav Rahul B RB Dumoux Maud M Hawes Chris C Botchway Stanley W SW
Scientific reports 20190304 1
Knowledge of protein signalling pathways in the working cell is seen as a primary route to identifying and developing targeted medicines. In recent years there has been a growing awareness of the importance of the mTOR pathway, making it an attractive target for therapeutic intervention in several diseases. Within this pathway we have focused on S6 kinase 1 (S6K1), the downstream phosphorylation substrate of mTORC1, and specifically identify its juxtaposition with mTORC1. When S6K1 is co-express ...[more]