Ontology highlight
ABSTRACT:
SUBMITTER: Lu J
PROVIDER: S-EPMC6399321 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Lu Jinghua J Van Laethem François F Bhattacharya Abhisek A Craveiro Marco M Saba Ingrid I Chu Jonathan J Love Nicholas C NC Tikhonova Anastasia A Radaev Sergei S Sun Xiaoping X Ko Annette A Arnon Tomer T Shifrut Eric E Friedman Nir N Weng Nan-Ping NP Singer Alfred A Sun Peter D PD
Nature communications 20190304 1
The αβ T cell receptor (TCR) repertoire on mature T cells is selected in the thymus, but the basis for thymic selection of MHC-restricted TCRs from a randomly generated pre-selection repertoire is not known. Here we perform comparative repertoire sequence analyses of pre-selection and post-selection TCR from multiple MHC-sufficient and MHC-deficient mouse strains, and find that MHC-restricted and MHC-independent TCRs are primarily distinguished by features in their non-germline CDR3 regions, wit ...[more]