Ontology highlight
ABSTRACT:
SUBMITTER: Bastian-Eugenio CE
PROVIDER: S-EPMC6399350 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Communications biology 20190304
Store-operated calcium entry (SOCE) is an essential calcium influx mechanism in animal cells. One of the most important auto regulatory control systems involves calcium-dependent inactivation (CDI) of the Orai channel, which prevents excessive calcium influx. In the present study we analyze the role of two channels in the induction of CDI on Orai1. Here we show that calcium entering through freely diffusing TRPV1 channels induce strong CDI on Orai1 while calcium entering through P2X<sub>4</sub> ...[more]