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Repeated social defeat induces transient glial activation and brain hypometabolism: A positron emission tomography imaging study.

ABSTRACT: Psychosocial stress is a risk factor for the development of depression. Recent evidence suggests that glial activation could contribute to the development of depressive-like behaviour. This study aimed to evaluate in vivo whether repeated social defeat (RSD) induces short- and long-term inflammatory and metabolic alterations in the brain through positron emission tomography (PET). Male Wistar rats ( n = 40) were exposed to RSD by dominant Long-Evans rats on five consecutive days. Behavioural and biochemical alterations were assessed at baseline, day 5/6 and day 24/25 after the RSD protocol. Glial activation (11C-PK11195 PET) and changes in brain metabolism (18F-FDG PET) were evaluated on day 6, 11 and 25 (short-term), and at 3 and 6 months (long-term). Defeated rats showed transient depressive- and anxiety-like behaviour, increased corticosterone and brain IL-1β levels, as well as glial activation and brain hypometabolism in the first month after RSD. During the third- and six-month follow-up, no between-group differences in any investigated parameter were found. Therefore, non-invasive PET imaging demonstrated that RSD induces transient glial activation and reduces brain glucose metabolism in rats. These imaging findings were associated with stress-induced behavioural changes and support the hypothesis that neuroinflammation could be a contributing factor in the development of depression.

SUBMITTER: Kopschina Feltes P

PROVIDER: S-EPMC6399731 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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Repeated social defeat induces transient glial activation and brain hypometabolism: A positron emission tomography imaging study.

Kopschina Feltes Paula P de Vries Erik Fj EF Juarez-Orozco Luis E LE Kurtys Ewelina E Dierckx Rudi Ajo RA Moriguchi-Jeckel Cristina M CM Doorduin Janine J

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20171222 3

Psychosocial stress is a risk factor for the development of depression. Recent evidence suggests that glial activation could contribute to the development of depressive-like behaviour. This study aimed to evaluate in vivo whether repeated social defeat (RSD) induces short- and long-term inflammatory and metabolic alterations in the brain through positron emission tomography (PET). Male Wistar rats ( n = 40) were exposed to RSD by dominant Long-Evans rats on five consecutive days. Behavioural and ...[more]

PMID: 29271288

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Dataset Information

Repeated social defeat induces transient glial activation and brain hypometabolism: A positron emission tomography imaging study.

Publications

Repeated social defeat induces transient glial activation and brain hypometabolism: A positron emission tomography imaging study.

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