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FoxP3 and Ezh2 Regulate Tfr cell Suppressive Function and Transcriptional Program

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE124884 | GEO | 2019/01/25

REPOSITORIES: GEO

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FoxP3 and Ezh2 regulate Tfr cell suppressive function and transcriptional program.

Project description:Follicular regulatory T (Tfr) cells are a regulatory T cell subset that controls antibody production by inhibiting T follicular helper (Tfh)-mediated help to B cells. Tfh and Tfr cells possess opposing functions suggesting unique programming. Here we elucidated the transcriptional program controlling Tfr suppressive function. We found that Tfr cells have a program for suppressive function fine-tuned by tissue microenvironment. The transcription factor FoxP3 and chromatin-modifying enzyme EZH2 are essential for this transcriptional program but regulate the program in distinct ways. FoxP3 modifies the Tfh program to induce a Tfr-like functional state, demonstrating that Tfr cells coopt the Tfh program for suppression. Importantly, we identified a Tfr cell population that loses the Tfr program to become "ex-Tfr" cells with altered functionality. These dysfunctional ex-Tfr cells may have roles in modulating pathogenic antibody responses. Taken together, our studies reveal mechanisms controlling the Tfr transcriptional program and how failure of these mechanisms leads to dysfunctional Tfr cells.

| S-EPMC6400538 | biostudies-literature

FoxP3 and Ezh2 Regulate Tfr cell Suppressive Function and Transcriptional Program [Ezh2]

Project description:Tfr cells from Ezh2 floxed FoxP3 Cre mice

2019-01-25 | GSE124881 | GEO

FoxP3 and Ezh2 Regulate Tfr cell Suppressive Function and Transcriptional Program [InVitro Ex-Tfr]

Project description:InVitro Ex-Tfr RNAseq

2019-01-25 | GSE124882 | GEO

FoxP3 and Ezh2 Regulate Tfr cell Suppressive Function and Transcriptional Program [tissue]

Project description:Tissue Specific Transcriptional Profiling of Tfh, Tfr, Treg and Tcon

2019-01-25 | GSE124883 | GEO

FoxP3 and Ezh2 Regulate Tfr cell Suppressive Function and Transcriptional Program [Ezh2]

Project description:FoxP3 and Ezh2 Regulate Tfr cell Suppressive Function and Transcriptional Program [Ezh2]

| PRJNA514079 | ENA

FoxP3 and Ezh2 Regulate Tfr cell Suppressive Function and Transcriptional Program

Project description:FoxP3 and Ezh2 Regulate Tfr cell Suppressive Function and Transcriptional Program

| PRJNA514077 | ENA

FoxP3 and Ezh2 Regulate Tfr cell Suppressive Function and Transcriptional Program [InVitro Ex-Tfr]

Project description:FoxP3 and Ezh2 Regulate Tfr cell Suppressive Function and Transcriptional Program [InVitro Ex-Tfr]

| PRJNA514080 | ENA

FoxP3 and Ezh2 Regulate Tfr cell Suppressive Function and Transcriptional Program [tissue]

Project description:FoxP3 and Ezh2 Regulate Tfr cell Suppressive Function and Transcriptional Program [tissue]

| PRJNA514078 | ENA

JunB modulates an IRF4-dependent transcriptional program to regulate homeostasis and suppressive functions of effector regulatory T cells

Project description:To understand molecular mechanisms by which JunB regulates Treg function, we performed RNA-seq and ChIP-seq analyses of JunB-deficient and control Treg cells (CD4+ CD25hi). This SuperSeries is composed of the SubSeries listed below.

2018-11-19 | GSE121295 | GEO

Identification of a core p53 transcriptional program with highly fractionated tumor suppressive activity

Project description:This SuperSeries is composed of the SubSeries listed below.

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