Assessing the causal association of glycine with risk of cardio-metabolic diseases.
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ABSTRACT:
SUBMITTER: Wittemans LBL
PROVIDER: S-EPMC6400990 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Publications
Assessing the causal association of glycine with risk of cardio-metabolic diseases.
Wittemans Laura B L LBL Lotta Luca A LA Oliver-Williams Clare C Stewart Isobel D ID Surendran Praveen P Karthikeyan Savita S Day Felix R FR Koulman Albert A Imamura Fumiaki F Zeng Lingyao L Erdmann Jeanette J Schunkert Heribert H Khaw Kay-Tee KT Griffin Julian L JL Forouhi Nita G NG Scott Robert A RA Wood Angela M AM Burgess Stephen S Howson Joanna M M JMM Danesh John J Wareham Nicholas J NJ Butterworth Adam S AS Langenberg Claudia C
Nature communications 20190305 1
Circulating levels of glycine have previously been associated with lower incidence of coronary heart disease (CHD) and type 2 diabetes (T2D) but it remains uncertain if glycine plays an aetiological role. We present a meta-analysis of genome-wide association studies for glycine in 80,003 participants and investigate the causality and potential mechanisms of the association between glycine and cardio-metabolic diseases using genetic approaches. We identify 27 genetic loci, of which 22 have not pr ...[more]
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