Dataset Information

The adverse association of animal zinc intake with cardio-cerebrovascular and metabolic risk factors.

ABSTRACT:

Background

The effect of zinc intake on cardio-cerebrovascular and metabolic diseases has always been controversial.

Aims

We hoped to evaluate the associations of the daily dietary estimate (DDE) of zinc intake with cardio-cerebrovascular and metabolic risk factors.

Methods

Baseline data from the Study of Women's Health Across the Nation (SWAN) were obtained. Multivariable linear regression analysis was used to examine associations of the DDE of zinc intake with cardio-cerebrovascular and metabolic risk factors.

Results

The smooth curve demonstrated positive associations of the DDE of animal zinc intake with low-density lipoprotein-cholesterol (LDL-C), triglycerides, total cholesterol, fasting blood glucose, insulin, systolic blood pressure (BP) and diastolic BP and an inverse association of the DDE of animal zinc intake with high-density lipoprotein-cholesterol (HDL-C). Consistently, multivariable linear regression models also showed that an increased DDE of animal zinc intake was closely related to a higher risk of cardio-cerebrovascular and metabolic risk factors [systolic BP: 0.37 (0.13, 0.61); diastolic BP: 0.17 (0.02, 0.33); fasting blood glucose: 1.13 (0.67, 1.59); insulin: 0.26 (0.05, 0.47); LDL-C: 0.82 (0.34, 1.29), triglycerides: 1.65 (0.75, 2.55), total cholesterol: 0.91 (0.38, 1.43) and HDL-C: -0.24 (-0.45, -0.03)] when age, race/ethnicity, total family income, smoking status, alcohol consumption and menopausal status were controlled for. Importantly, stratified analysis supported that the independent associations between the DDE of animal zinc intake and risk factors for cardio-cerebrovascular and metabolic diseases were hardly affected by age and body mass index (BMI).

Conclusion

We found that an increased DDE of animal zinc intake was associated with higher cardiovascular and metabolic risks among middle-aged women, which did not support the benefit of zinc intake in reducing cardiovascular and metabolic risks. The association seems to be incongruous with the anti-inflammation and antioxidation physiological functions of zinc. Thus, additional well-designed and prospective studies are needed to confirm this association.

SUBMITTER: Zou SF

PROVIDER: S-EPMC10765292 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature

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Publications

The adverse association of animal zinc intake with cardio-cerebrovascular and metabolic risk factors.

Zou Shu Feng SF Jiang Bixia B Wan Rong R Huang Ying Y

International journal of cardiology. Cardiovascular risk and prevention 20231209

<h4>Background</h4>The effect of zinc intake on cardio-cerebrovascular and metabolic diseases has always been controversial.<h4>Aims</h4>We hoped to evaluate the associations of the daily dietary estimate (DDE) of zinc intake with cardio-cerebrovascular and metabolic risk factors.<h4>Methods</h4>Baseline data from the Study of Women's Health Across the Nation (SWAN) were obtained. Multivariable linear regression analysis was used to examine associations of the DDE of zinc intake with cardio-cere ...[more]

PMID: 38179184

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Dataset Information

The adverse association of animal zinc intake with cardio-cerebrovascular and metabolic risk factors.

Background

Aims

Methods

Results

Conclusion

Publications

The adverse association of animal zinc intake with cardio-cerebrovascular and metabolic risk factors.

Similar Datasets

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