Ontology highlight
ABSTRACT:
SUBMITTER: Piccirillo G
PROVIDER: S-EPMC6401126 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Piccirillo G G Carvajal Berrio D A DA Laurita A A Pepe A A Bochicchio B B Schenke-Layland K K Hinderer S S
Scientific reports 20190305 1
Electrospinning is an attractive method to generate drug releasing systems. In this work, we encapsulated the cell death-inducing drug Diclofenac (DCF) in an electrospun poly-L-lactide (PLA) scaffold. The scaffold offers a system for a sustained and controlled delivery of the cytotoxic DCF over time making it clinically favourable by achieving a prolonged therapeutic effect. We exposed human dermal fibroblasts (HDFs) to the drug-eluting scaffold and employed multiphoton microscopy and fluorescen ...[more]