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Multisite atherosclerosis in subjects with metabolic syndrome and diabetes and relation to cardiovascular events: The Multi-Ethnic Study of Atherosclerosis.


ABSTRACT: BACKGROUND AND AIMS:The extent and relation of multisite atherosclerosis to cardiovascular disease (CVD) in metabolic syndrome (MetS) and diabetes (DM) are not well documented. We examined the extent of multisite atherosclerosis and its prognostic value for CVD events in MetS and DM. METHODS:In CVD-free subjects from the Multi-Ethnic Study of Atherosclerosis, multisite atherosclerosis was measured as: (1) the number of arterial beds involved (coronary calcium>0, abdominal aortic calcium>0, carotid intima-media thickness ?1?mm and ankle brachial index<1 or ?1.4); (2) a composite score summing the quartile rank for each atherosclerosis measure. Hazard ratios (HRs) and c-statistics were calculated for incident CVD and coronary heart disease (CHD) over 10.6 years. RESULTS:Of 1675 individuals (mean age 64 years, 51% male), 33.4% had MetS and 15.9% had DM. The number of atherosclerotic sites was higher in those with DM (mean?±?SD?=?1.67?±?1.15) and MetS (1.49?±?1.12) versus neither MetS/DM (1.09?±?1.09) (p?

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC6401246 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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Multisite atherosclerosis in subjects with metabolic syndrome and diabetes and relation to cardiovascular events: The Multi-Ethnic Study of Atherosclerosis.

Zhao Yanglu Y   Evans Marcella A MA   Allison Matthew A MA   Bertoni Alain G AG   Budoff Matthew J MJ   Criqui Michael H MH   Malik Shaista S   Ouyang Pamela P   Polak Joseph F JF   Wong Nathan D ND  

Atherosclerosis 20181215


<h4>Background and aims</h4>The extent and relation of multisite atherosclerosis to cardiovascular disease (CVD) in metabolic syndrome (MetS) and diabetes (DM) are not well documented. We examined the extent of multisite atherosclerosis and its prognostic value for CVD events in MetS and DM.<h4>Methods</h4>In CVD-free subjects from the Multi-Ethnic Study of Atherosclerosis, multisite atherosclerosis was measured as: (1) the number of arterial beds involved (coronary calcium>0, abdominal aortic c  ...[more]

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