Ontology highlight
ABSTRACT:
SUBMITTER: Liu J
PROVIDER: S-EPMC6401363 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Liu Jing J Zhou Jie J Wu Min M Hu ChuanFei C Yang Juan J Li Dong D Wu Peng P Chen Yue Y Chen Ping P Lin Sheng S Cui YongXia Y Fu ShaoZhi S Wu JingBo J
Frontiers in immunology 20190227
A systemic immune related response (SIME) of radiotherapy has been occasionally observed on metastatic tumors, but the clinical outcomes remain poor. Novel treatment approaches are therefore needed to improve SIME ratio. We used a combination of hypo-fractionated radiation therapy (H-RT) with low-dose total body irradiation (L-TBI) in a syngeneic mouse model of breast and colon carcinoma. The combination therapy of H-RT and L-TBI potentially enhanced SIME by infiltration of CD8<sup>+</sup> T cel ...[more]