Ontology highlight
ABSTRACT:
SUBMITTER: Yang ZZ
PROVIDER: S-EPMC6402596 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Yang Zhi-Zhang ZZ Kim Hyo Jin HJ Villasboas Jose C JC Price-Troska Tammy T Jalali Shahrzad S Wu Hongyan H Luchtel Rebecca A RA Polley Mei-Yin C MC Novak Anne J AJ Ansell Stephen M SM
Cell reports 20190201 8
Follicular lymphoma (FL) is an indolent B cell malignancy characterized by an extensive but poorly functional T cell infiltrate in the tumor microenvironment. Using mass cytometry, we identified at least 12 subsets of intratumoral CD4<sup>+</sup> T cells, 3 of which were unique to FL biopsies versus control tissues. Of these subsets, the frequency of naive T cells correlated with improved patient survival. Although total PD-1<sup>+</sup> T cell numbers were not associated with patient outcome, s ...[more]