Ontology highlight
ABSTRACT:
SUBMITTER: Sabin KZ
PROVIDER: S-EPMC6403268 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Sabin Keith Z KZ Jiang Peng P Gearhart Micah D MD Stewart Ron R Echeverri Karen K
Communications biology 20190306
Salamanders have the remarkable ability to functionally regenerate after spinal cord transection. In response to injury, GFAP<sup>+</sup> glial cells in the axolotl spinal cord proliferate and migrate to replace the missing neural tube and create a permissive environment for axon regeneration. Molecular pathways that regulate the pro-regenerative axolotl glial cell response are poorly understood. Here we show axolotl glial cells up-regulate AP-1<sup>cFos/JunB</sup> after injury, which promotes a ...[more]