Ontology highlight
ABSTRACT:
SUBMITTER: Uluckan O
PROVIDER: S-EPMC6856727 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Uluçkan Özge Ö Jiménez Maria M Roediger Ben B Schnabl Jakob J Díez-Córdova Lucía T LT Troulé Kevin K Weninger Wolfgang W Wagner Erwin F EF
Cell reports 20191001 4
Atopic dermatitis (AD) is a multi-factorial skin disease with a complex inflammatory signature including type 2 and type 17 activation. Although colonization by S. aureus is common in AD, the mechanisms rendering an organism prone to dysbiosis, and the role of IL-17A in the control of S. aureus-induced skin inflammation, are not well understood. Here, we show several pathological aspects of AD, including type 2/type 17 immune responses, elevated IgE, barrier dysfunction, pruritus, and importantl ...[more]