Dataset Information

Functionalization of Molecularly Imprinted Polymer Microspheres for the Highly Selective Removal of Contaminants from Aqueous Solutions and the Analysis of Food-Grade Fish Samples.

ABSTRACT: The proliferation of pollution in aquatic environments has become a growing concernand calls for the development of novel adsorbents capable of selectively removing notorious andrecalcitrant pollutants from these ecosystems. Herein, a general strategy was developed for thesynthesis and functionalization of molecularly imprinted polymer microspheres (MIPs) that couldbe optimized to possess a significant adsorption selectivity to an organic pollutant in aqueousmedia, in addition to a high adsorption capacity. Considering that the molecular imprinting alonewas far from satisfactory to produce a high-performance MIPs-based adsorbent, further structuralengineering and surface functionalization were performed in this study. Although the more carboxylgroups on the surfaces of the MIPs enhanced the adsorption rate and capacity toward an organicpollutant through electrostatic interactions, they did not strengthen the adsorption selectivity in aproportional manner. Through a systematic study, the optimized sample exhibiting both impressiveselectivity and capacity for the adsorption of the organic pollutant was found to possess a smallparticle size, a high specific surface area, a large total pore volume, and an appropriate amount ofsurface carboxyl groups. While the pseudo-second-order kinetic model was found to better describethe process of the adsorption onto the surface of MIPs as compared to the pseudo-first-order kineticmodel, neither Langmuir nor Freundlich isothermal model could be used to well fit the isothermaladsorption data. Increased temperature facilitated the adsorption of the organic pollutant onto theMIPs, as an endothermic process. Furthermore, the optimized MIPs were also successfully employedas a stationary phase for the fabrication of a molecularly imprinted solid phase extraction column,with which purchased food-grade fish samples were effectively examined.

SUBMITTER: Liang W

PROVIDER: S-EPMC6403773 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

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Functionalization of Molecularly Imprinted Polymer Microspheres for the Highly Selective Removal of Contaminants from Aqueous Solutions and the Analysis of Food-Grade Fish Samples.

Liang Weixin W Hu Huawen H Zhong Wanting W Zhang Min M Ma Yanfang Y Guo Pengran P Xin Meiguo M Yu Mingguang M Lin Haisheng H

Polymers 20181011 10

The proliferation of pollution in aquatic environments has become a growing concernand calls for the development of novel adsorbents capable of selectively removing notorious andrecalcitrant pollutants from these ecosystems. Herein, a general strategy was developed for thesynthesis and functionalization of molecularly imprinted polymer microspheres (MIPs) that couldbe optimized to possess a significant adsorption selectivity to an organic pollutant in aqueousmedia, in addition to a high adsorpti ...[more]

PMID: 30961055

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Project description:The noxious clenbuterol misapplied as the feed additive has posed an enormous threat to humans who actively rely on the food chains with high potential of contamination by clenbuterol, such as pork and beef. It is, therefore, highly desirable to develop novel materials and strategies for dealing with the clenbuterol. Herein, functional polymer microspheres prepared by Pickering emulsion polymerization were explored for the selective enrichment of the clenbuterol, and their structure and oxygen functionalities could be tailor-made by a molecular imprinting process. The clenbuterol imprinting was adequately demonstrated to not only increase the particle size (~52 nm vs. ~42 nm) and create cavities for the accommodation of the clenbuterol molecules, but also reduce the oxygen functionalities of the resulting molecularly imprinted polymer microspheres (MIPMs) by approximately 4 at.%, which is believed to correlate with the high specificity of the MIPMs. Various characterization methods were employed to evidence these findings, including scanning electron microscopy, BET measurements, Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, and elemental mapping examination. More importantly, the MIPMs showed a markedly superior enrichment capability towards clenbuterol to the counterpart, that is, non-molecularly imprinted polymer microspheres (NIPMs). Compared to the NIPMs without specificity for clenbuterol, the MIPMs exhibited an impressive selectivity to clenbuterol, with the relative selectivity coefficient (k') values largely exceeding 1, thus corroborating that the useful molecular imprinting led to the generation of the binding sites complementary to the clenbuterol molecule in the size and functionalities. The MIPMs were also employed as the stationary phase to fabricate molecularly imprinting solid-phase extraction column, and the spike recovery was demonstrated to be not significantly decreased even after nine cycles. Furthermore, the reliability of the method was also evidenced through the comparison of the MIPMs prepared from different batches.

Project description:In this article we describe a new class of high-density optical microarrays based on molecularly imprinted microsphere sensors that directly incorporate specific recognition capabilities to detect enrofloxacin (ENRO), an antibiotic widely used for both human and veterinary applications. This approach involves the preparation of highly cross-linked polymer microspheres by thermal precipitation-polymerization in the presence and absence of the target analyte ENRO to generate either molecularly imprinted (MIP) or non-imprinted polymer (NIP) microspheres, respectively. Each polymer type of tailor-made microsphere is fluorescently encoded with either coumarin-30 or tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(ii) dichloride [Ru(dip)3]Cl2 to enable the microspheres to be distinguished. The new MIP-based sensing platform utilizes an optical fiber bundle containing approximately 50 000 individual 3.1 μm diameter fibers that are chemically etched to create microwells in which MIP and NIP microspheres can be deposited and imaged using an epi-fluorescence microscope. The method enables multiplexed detection by independently addressing both types of beads through their separate light channels. The unique response to the presence of ENRO is manifested on the basis of a competitive immunoassay. A red-fluorescent dye-tagged ENRO, labeled with BODIPY® TR Cadaverine, competes with ENRO for specific binding sites. The developed immuno-like assay displayed a limit of detection (LOD) of 0.04 μM (10% binding inhibition) and a dynamic range of 0.29-21.54 μM (20-80% binding inhibition). The selectivity of the assay was evaluated by measuring the cross-reactivity of other fluoroquinolones (ciprofloxacin, norfloxacin, danofloxacin, and flumequine) and non-related antibiotics (penicillin G and doxycycline). This work demonstrates, for the first time, the applicability of MIPs, as an alternative to biomolecule receptors, for the development of multiplexed detection fiber-optic microarrays paving the way for a new generation of biomimetic sensors.

Dataset Information

Functionalization of Molecularly Imprinted Polymer Microspheres for the Highly Selective Removal of Contaminants from Aqueous Solutions and the Analysis of Food-Grade Fish Samples.

Publications

Functionalization of Molecularly Imprinted Polymer Microspheres for the Highly Selective Removal of Contaminants from Aqueous Solutions and the Analysis of Food-Grade Fish Samples.

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