Ontology highlight
ABSTRACT:
SUBMITTER: Guenther CM
PROVIDER: S-EPMC6404099 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Guenther Caitlin M CM Brun Mitchell J MJ Bennett Antonette D AD Ho Michelle L ML Chen Weitong W Zhu Banghe B Lam Michael M Yamagami Momona M Kwon Sunkuk S Bhattacharya Nilakshee N Sousa Duncan D Evans Annicka C AC Voss Julie J Sevick-Muraca Eva M EM Agbandje-McKenna Mavis M Suh Junghae J
Molecular therapy : the journal of the American Society of Gene Therapy 20190129 3
Adeno-associated virus (AAV) has emerged as a promising gene delivery vector because of its non-pathogenicity, simple structure and genome, and low immunogenicity compared to other viruses. However, its adoption as a safe and effective delivery vector for certain diseases relies on altering its tropism to deliver transgenes to desired cell populations. To this end, we have developed a protease-activatable AAV vector, named provector, that responds to elevated extracellular protease activity comm ...[more]