Evaluation of the photo-degradation of Alzheimer's amyloid fibrils with a label-free approach.
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ABSTRACT:
SUBMITTER: Wang T
PROVIDER: S-EPMC6404227 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
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Evaluation of the photo-degradation of Alzheimer's amyloid fibrils with a label-free approach.
Wang Tianke T Zhang Liwei L Wang Jie J Feng Yonghai Y Xu Enquan E Mao Xiaobo X Liu Lei L
Chemical communications (Cambridge, England) 20181101 93
Degradation of amyloid-β (Aβ) aggregates has been considered as an attractive therapeutic and preventive strategy against Alzheimer's disease (AD). However, an in situ, real-time, and label-free technique is still lacking to understand the degradation process of Aβ aggregates. In this work, we developed a novel method to quantitatively evaluate the degradation of Aβ fibrils by photoactive meso-tetra(4-sulfonatophenyl)porphyrin under UV irradiation with quartz crystal microbalance (QCM). ...[more]
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