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Design and application of a modular and scalable electrochemical flow microreactor.

ABSTRACT: Electrochemistry constitutes a mild, green and versatile activation method of organic molecules. Despite these innate advantages, its widespread use in organic chemistry has been hampered due to technical limitations, such as mass and heat transfer limitations which restraints the scalability of electrochemical methods. Herein, we describe an undivided-cell electrochemical flow reactor with a flexible reactor volume. This enables its use in two different modes, which are highly relevant for flow chemistry applications, including a serial (volume ranging from 88 ?L/channel up to 704 ?L) or a parallel mode (numbering-up). The electrochemical flow reactor was subsequently assessed in two synthetic transformations, which confirms its versatility and scale-up potential.

SUBMITTER: Laudadio G

PROVIDER: S-EPMC6404740 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Design and application of a modular and scalable electrochemical flow microreactor.

Laudadio Gabriele G de Smet Wouter W Struik Lisa L Cao Yiran Y Noël Timothy T

Journal of flow chemistry 20181122 3

Electrochemistry constitutes a mild, green and versatile activation method of organic molecules. Despite these innate advantages, its widespread use in organic chemistry has been hampered due to technical limitations, such as mass and heat transfer limitations which restraints the scalability of electrochemical methods. Herein, we describe an undivided-cell electrochemical flow reactor with a flexible reactor volume. This enables its use in two different modes, which are highly relevant for flow ...[more]

PMID: 30931153

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