Dataset Information

Cutaneous leishmaniasis and co-morbid major depressive disorder: A systematic review with burden estimates.

ABSTRACT:

Background

Major depressive disorder (MDD) associated with chronic neglected tropical diseases (NTDs) has been identified as a significant and overlooked contributor to overall disease burden. Cutaneous leishmaniasis (CL) is one of the most prevalent and stigmatising NTDs, with an incidence of around 1 million new cases of active CL infection annually. However, the characteristic residual scarring (inactive CL) following almost all cases of active CL has only recently been recognised as part of the CL disease spectrum due to its lasting psychosocial impact.

Methods and findings

We performed a multi-language systematic review of the psychosocial impact of active and inactive CL. We estimated inactive CL (iCL) prevalence for the first time using reported WHO active CL (aCL) incidence data that were adjusted for life expectancy and underreporting. We then quantified the disability (YLD) burden of co-morbid MDD in CL using MDD disability weights at three severity levels. Overall, we identified 29 studies of CL psychological impact from 5 WHO regions, representing 11 of the 50 highest burden countries for CL. We conservatively calculated the disability burden of co-morbid MDD in CL to be 1.9 million YLDs, which equalled the overall (DALY) disease burden (assuming no excess mortality in depressed CL patients). Thus, upon inclusion of co-morbid MDD alone in both active and inactive CL, the DALY burden was seven times higher than the latest 2016 Global Burden of Disease study estimates, which notably omitted both psychological impact and inactive CL.

Conclusions

Failure to include co-morbid MDD and the lasting sequelae of chronic NTDs, as exemplified by CL, leads to large underestimates of overall disease burden.

SUBMITTER: Bailey F

PROVIDER: S-EPMC6405174 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Cutaneous leishmaniasis and co-morbid major depressive disorder: A systematic review with burden estimates.

Bailey Freddie F Mondragon-Shem Karina K Haines Lee Rafuse LR Olabi Amina A Alorfi Ahmed A Ruiz-Postigo José Antonio JA Alvar Jorge J Hotez Peter P Adams Emily R ER Vélez Iván D ID Al-Salem Waleed W Eaton Julian J Acosta-Serrano Álvaro Á Molyneux David H DH

PLoS neglected tropical diseases 20190225 2

<h4>Background</h4>Major depressive disorder (MDD) associated with chronic neglected tropical diseases (NTDs) has been identified as a significant and overlooked contributor to overall disease burden. Cutaneous leishmaniasis (CL) is one of the most prevalent and stigmatising NTDs, with an incidence of around 1 million new cases of active CL infection annually. However, the characteristic residual scarring (inactive CL) following almost all cases of active CL has only recently been recognised as ...[more]

PMID: 30802261

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Dataset Information

Cutaneous leishmaniasis and co-morbid major depressive disorder: A systematic review with burden estimates.

Background

Methods and findings

Conclusions

Publications

Cutaneous leishmaniasis and co-morbid major depressive disorder: A systematic review with burden estimates.

Similar Datasets

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