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ABSTRACT: Objective
To evaluate the basal/total ratio of daily insulin dose (b/T) in outpatients with diabetes type 1 (DM1) and type 2 (DM2) on basal-bolus regimen, by investigating whether there is a relationship with HbA1c and episodes of hypoglycemia.Methods
Multicentric, observational, cross-sectional study in Italy. Adult DM1 (n?=?476) and DM2 (n?=?541) outpatients, with eGFR >30 mL/min/1.73 m2, on a basal-bolus regimen for at least six months, were recruited from 31 Italian Diabetes services between March and September 2016. Clinicaltrials.govID: NCT03489031.Results
Total daily insulin dose was significantly higher in DM2 patients (52.3?±?22.5 vs. 46?±?20.9 U/day), but this difference disappeared when insulin doses were normalized for body weight. The b/T ratio was lower than 0.50 in both groups: 0.46?±?0.14 in DM1 and 0.43?±?0.15 in DM2 patients (p?=?0.0011). The b/T was significantly higher in the patients taking metformin in both groups, and significantly different according to the type of basal insulin (Degludec, 0.48 in DM1 and 0.44 in DM2; Glargine, 0.44 in DM1 and 0.43 in DM2; Detemir, 0.45 in DM1 and 0.39 in DM2). The b/T ratio was not correlated in either group to HbA1c or incidence of hypoglycemia (<40 mg/dL, or requiring caregiver intervention, in the last three months). In the multivariate analysis, metformin use and age were independent predictors of the b/T ratio in both DM1 and DM2 patients, while the type of basal insulin was an independent predictor only in DM1.Conclusion
The b/T ratio was independent of glycemic control and incidence of hypoglycemia.
SUBMITTER: Castellano E
PROVIDER: S-EPMC6405380 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Journal of diabetes and metabolic disorders 20181001 2
<h4>Objective</h4>To evaluate the basal/total ratio of daily insulin dose (b/T) in outpatients with diabetes type 1 (DM1) and type 2 (DM2) on basal-bolus regimen, by investigating whether there is a relationship with HbA1c and episodes of hypoglycemia.<h4>Methods</h4>Multicentric, observational, cross-sectional study in Italy. Adult DM1 (<i>n</i> = 476) and DM2 (<i>n</i> = 541) outpatients, with eGFR >30 mL/min/1.73 m<sup>2</sup>, on a basal-bolus regimen for at least six months, were recruited ...[more]